Fig. 1: MERS-CoV entry is mediated by two distinct entry pathways. | npj Viruses

Fig. 1: MERS-CoV entry is mediated by two distinct entry pathways.

From: Middle East respiratory syndrome coronavirus (MERS-CoV) internalization does not rely on DPP4 cytoplasmic tail signaling

Fig. 1

a Representative brightfield fluorescence image and a corresponding graph showing a reduction in the percentage of infection of MERS-PV-GFP in Huh7 cells upon treatment with MERS-CoV spike polyclonal antibody, compared to the mock-treated group (b) and (c) Bar graph showing the percentage of neutralization of MERS-CoV PV infection in Huh7 cells and HEK293T cells transiently expressing DPP4, respectively d Relative percentage difference in MERS-CoV PV infection on HEK293T cells transiently expressing either pcDNA, DPP4 alone, TMPRSS2 alone or DPP4 + TMPRSS2 both (e–g) Percentage of relative MERS-CoV PV infection in Huh7, Vero and Calu3 respectively on treatment with 100 µM Camostat mesylate, N = 3, bar graphs represent mean ± SEM, ns non-significant, * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

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