Fig. 3: MERS-CoV spike interaction with mutant DPP4 and permissivity of MERS-CoV pseudotyped virus in DPP4 mutant expressing cells. | npj Viruses

Fig. 3: MERS-CoV spike interaction with mutant DPP4 and permissivity of MERS-CoV pseudotyped virus in DPP4 mutant expressing cells.

From: Middle East respiratory syndrome coronavirus (MERS-CoV) internalization does not rely on DPP4 cytoplasmic tail signaling

Fig. 3

a HEK293T cells transiently transfected with wtDPP4, ΔK6DPP4, ΔcytDPP4 or pcDNA showing receptor expression (red) and MERS-CoV spike S1 protein binding (green) upon immunostaining, scale bar = 50 µm (b) and (c) MERS-CoV infection in two non-susceptible cell lines HEK293T and BHK-21 respectively, transiently expressing wtDPP4 and its different mutants, N = 2, bar graphs represent mean ± SEM (HEK293T) and mean ± SD (BHK-21), * p < 0.05; ** p < 0.01; *** p < 0.001.

Back to article page