Fig. 1: Structural homology between α-bungarotoxin (α-Bgtx) and HSV1gD.
From: HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors
a The nAChR 3FTx loop 2 binding region of α-Bgtx is shown in red. b A loop region in HSV1gD that displays significant structural homology to the 3FTX loop 2 region of α-Bgtx is shown in blue. c The homologous loop structures of α-Bgtx 3Ftx loop (red) and HSV1 gD (blue) are overlapped using the TM-align algorithm (RMSD = 1.981 Å). A close-up view of the model (right) depicts specific amino acids side chain alignments. d The homologous loop structures of α-Bgtx 3Ftx loop (red) and HSV1 gD (blue) are overlapped using the jFATCAT algorithm (RMSD = 2.249 Å). A close-up view of the model indicates the alignment of individual amino acid side chains.
