Table 2 Comparison of IC50 and Ki values for functional inhibition of α7 nAChRs by HSV1 gD whole ectodomain, the 92AA fragment and the 24AA peptide
From: HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors
HSV1 gD proteins/peptides | IC50 and Ki |
|---|---|
Whole ectodomain | IC50 = 0.85 µM, (95% CI: 0.55 to 1.14 µM), Ki = 0.53 µM |
92AA HSV1 gD protein | IC50 = 2.68 µM, 95% CI: 2.19–3.27 µM, Ki = 1.19 µM |
24AA HSV1 gD peptide | IC50 = 157 µM, (95% CI: 132 µM to 186 µM), Ki = 69.78 µM |
