Table 1 Hemagglutination inhibition (HI) assay of recombinant viruses with TRBCa

From: Impact of naturally occurring hemagglutinin substitutions on antigenicity and fitness of influenza A(H5N1) virus

Virus strain name

Clade

Ferret antisera

2.3.4.4b

2.3.4.4b

2.3.4.4b

2.3.4.4c

2.3.4.4 g

2.3.2.1a

2.3.4.4b

2.3.4.4b

2.3.4.4b

2.3.4.4b

IDCDC-RG71A

IDCDC-RG78A

IDCDC-RG80A

IDCDC-RG43A

IDCDC-RG69A

IDCDC-RG63A

AW/2021

Chile/2023

TX37

MI90

Homologous titer

320

160

2560

80

80

320

160

40

80

160

WT TX37 isolate

2.3.4.4b

320

320

2560

320

80

320

160

40

80

160

rTX37

2.3.4.4b

160

160

2560

320

40

320

160

40

80

160

rTX37-HA-P136S

2.3.4.4b

160

160

2560

160

40

160

80

20

80

80

rTX37-HA-A156T

2.3.4.4b

80

20

2560

20

<10

<10

20

10

80

320

rTX37-HA-P136S/A156T

2.3.4.4b

80

40

2560

10

<10

<10

20

10

80

320

  1. aPrototype viruses for CVVs: IDCDC-RG71A (A/Astrakhan/3212/2020), IDCDC-RG78A (A/American Wigeon/South Carolina/22-000345-001/2021), IDCDC-RG80A (A/chicken/Ghana/AVL-763_21VIR7050-39/2021), IDCDC-RG43A (A/gyrfalcon/Washington/41088-6/2014), IDCDC-RG63A (A/duck/Bangladesh/17D1012/2018), IDCDC-RG69A (A/ck/Vietnam/RAHO4-CD-20-421/2020). AW/2021 A/American Wigeon/South Carolina/22-000345-001/2021, Chile/2023 A/Chile/25945/2023, TX37 A/Texas/37/2024, MI90 A/Michigan/90/2024.
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