Table 2 The neutralization titer 50 (NT50) of ferret antisera against the recombinant viruses by Focus Reduction Assaya

From: Impact of naturally occurring hemagglutinin substitutions on antigenicity and fitness of influenza A(H5N1) virus

Virus strain name

Clade

Ferret antisera

2.3.4.4b

2.3.4.4b

2.3.4.4b

2.3.4.4c

2.3.4.4 g

2.3.2.1a

2.3.4.4b

2.3.4.4b

2.3.4.4b

2.3.4.4b

IDCDC-RG71A

IDCDC-RG78A

IDCDC-RG80A

IDCDC-RG43A

IDCDC-RG69A

IDCDC-RG63A

AW/2021

Chile/2023

TX37

MI90

Homologous titer

34995

5888

77384

31421

16767

4972

5037

2275

936

5245

TX37 isolate

2.3.4.4b

23844 (1.5)

3047 (1.9)

40355 (1.9)

14403 (2.2)

1708 (9.8)

7005 (0.7)

5216 (1.0)

1528 (1.5)

851 (1.1)

5868 (0.9)

rTX37

2.3.4.4b

23733 (1.5)

3187 (1.8)

36923 (2.1)

12620 (2.5)

2106 (8.0)

8984 (0.6)

5484 (0.9)

2115 (1.1)

868 (1.1)

5554 (0.9)

rTX37-HA-P136S

2.3.4.4b

22526 (1.6)

2905 (2.0)

35014 (2.2)

14107 (2.2)

1851 (9.1)

6412 (0.8)

4232 (1.2)

1032 (2.2)

689 (1.4)

4223 (1.2)

rTX37-HA-A156T

2.3.4.4b

5684 (6.2)

357 (16.5)

48574 (1.6)

194 (162.0)

162 (103.5)

<50 (>99.4)

214 (23.5)

<50 (>45.5)

<50 (>18.7)

269 (19.5)

rTX37-HA-P136S/A156T

2.3.4.4b

4525 (7.7)

390 (15.1)

42615 (1.8)

199 (157.9)

212 (79.1)

<50 (>99.4)

280 (18.0)

62 (36.7)

<50 (>18.7)

380 (13.8)

  1. aThe value in parentheses represents the fold change between the homologous titer and the neutralization titer of recombinant virus.
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