Fig. 1: Developments in PET radiotracers for imaging mHTT aggregates. | npj Imaging

Fig. 1: Developments in PET radiotracers for imaging mHTT aggregates.

From: Emerging targets for positron emission tomography imaging in proteinopathies

Fig. 1

A Evolution of CHDI mHTT radiotracers to date. B Longitudinal [11C]CHDI-180R images in wild-type and zQ175DN heterozygous mHTT expressing mice. Adapted from Bertoglio, D. et al. Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease. Sci. Transl. Med. 14, eabm3682 (2022). Reprinted with permission from AAAS. C Quantification of [3H]CHDI-180 and [3H]CHDI-626 binding in HD, healthy control (HC) and AD human brain homogenates. Adapted from Herrmann, F. et al. Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Sci. Rep. 11, 17977 (2021).

Back to article page