Fig. 2: Magnetic field dependence of the BOLD functional contrast-to-noise ratio (fCNR).
From: Advanced preclinical functional magnetic resonance imaging of the brain
a Signal amplitude of micro-vasculature as a function of magnetic field strength for gradient echo (GE, blue) and spin echo (SE, red) EPI sequences, normalized to 3 T and scaled with B01.6515. Taken with modifications from [Uludag and Blinder 2018]77. b Field strength-dependent (9.4 Tesla vs. 15.2 Tesla) BOLD response to 20-s forepaw stimulation in lightly anesthetized mice. Multi-slice fMRI maps of i) one representative animal overlaid on the original EPI image with a statistical threshold (uncorrected p < 0.001, cluster size >5 voxels) and ii) group-averaged analysis without statistical thresholds (n = 7, respectively) at each magnetic field. c fMRI time courses (average of seven animals) obtained from the region-of-interest of the contralateral S1FL and thalamus were plotted for 9.4 Tesla (red) and 15.2 Tesla (blue). Error bars, SEM; gray horizontal bar, 20-s stimulus duration. d Field strength-dependent statistical t values from four different ROIs of contralateral forelimb primary somatosensory area (Cont.S1FL), thalamus (Cont.Thal), secondary somatosensory area (Cont.S2), and ipsilateral primary somatosensory area (Ipsi.S1FL). error bars, SEM; *p < 0.05 (n = 7, independent t test). Taken from [Jung 2019]18.
