Fig. 7: fMRI in animal models of psychiatric and neurological disorder.

a–d Functional connectivity deficits in mouse models of autism. The mapping reveals a spectrum of four functional connectivity subtypes. a Rendering of regional connectivity deficits in the four clusters at the node level, revealing a heterogeneous set of brain areas with prominent over- and under-connectivity. Data are visualized in Allen Mouse reference space. b Number of connections (displayed as stacked frequencies) that exhibited abnormalities at the parent level. c Correlation matrix between all clusters, considering all 545 edges. d A significant negative correlation was found between Cluster 1 and Cluster 4. Spearman’s rho = −0.48, p = 1.96e^-157. Taken from [Zerbi 2021]⁷². e, f Therapeutic rescue of reduced functional connectivity in a mouse model of neurofibromatosis type 1. e Group average correlation maps between control and mice with oligodendrocyte-specific Nf1 deletion (Plp-Nf1^fl/+) demonstrate reduced interhemispheric connectivity in Plp-Nf1^fl/+ mice. Z(r) Fisher’s Z-transformed r, MOp primary motor cortex, SSp primary somatosensory cortex. f Rescue of connectivity in Plp-Nf1^fl/+ mice by inhibition of nitric oxide synthase. Correlation of seed-to-seed analysis in the primary motor cortex (denoted as a plus sign in the maps shown in e, plotted for each group before and after L-arginine methyl ester (L-NAME) treatment. Taken from Asleh⁷⁵.