Fig. 4: The role of copper-mediated radiolabeling in pretargeting.
From: Copper-mediated radiochemistry: historical impact, current trends, and future possibilities
A Schematic for in vivo pretargeting. Recreated from ref. 83 (using https://BioRender.com) with permission©, SNMMI. B The rapid biorthogonal inverse-electron-demand Diels–Alder (click) reaction between trans-cyclooctene and an aryl tetrazine serves as the chemical basis for some in vivo pretargeting approaches. C Copper-mediated Radiofluorination was successfully employed to radiolabel methyl-phenyl-tetrazine. Adapted from ref. 85 under a Creative Commons Attribution 3.0 Unported Licence.
