Fig. 5: Visualisation of lipidomic heterogeneity in ccRCC tumoroids. | npj Imaging

Fig. 5: Visualisation of lipidomic heterogeneity in ccRCC tumoroids.

From: Kidney tumoroid characterisation by spatial mass spectrometry with same-section multiplex immunofluorescence uncovers tumour microenvironment lipid signatures associated with aggressive tumour phenotypes

Fig. 5

DESI-MSI ion images of m/z 707.5013 (PA O-38:5, blue), m/z 790.5411 (PE 40:6, red) and m/z 887.5606 (PI 38:3, yellow) showing distinct lipid distributions in tumoroids. H&E and mIF images post-DESI-MSI reveal regions with proliferative cells (Ki67, green), endothelial cells (CD105, red) and PanCK+ cells (pink).

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