Fig. 3: CJ215 offers enhanced targeting and contrast in vivo for tumor labeling. | npj Imaging

Fig. 3: CJ215 offers enhanced targeting and contrast in vivo for tumor labeling.

From: Phosphatidylserine exposure and plasma membrane perforation as ferroptotic signatures for in vivo imaging

Fig. 3

a IVIS imaging of HT1080 xenograft tumor bearing nude mice injected with AnnexinVivo dye shows kidney localization at 24, 48 and 72 h, b IVIS imaging of HT1080 xenograft tumor bearing nude mice injected with CJ215 dye shows tumor localization at 24, 48 and 72 h with decreasing background over time. c Biodistribution of CJ215 at different organs of HT1080 xenograft tumor-bearing nude mice at 72 h shows increased fluorescence in tumor, intestine and kidney, showing the excretion routes of CJ215, n = 5 mice. Intestinal signal is also in part attributable to chlorophyl fluorochromes in the animals’ food. Mean ± s.d. p values are reported above the lines (Ordinary one-way ANOVA with Tukey’s multiple comparisons). Scalebar 50 mm.

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