Table 2 Cosinor analysis of proteins identified as having a significant rhythm (p < 0.05) versus H0 of no rhythmicity
Protein (gene) with 12 hour rhythm | Uniprot ID | Acrophase (DLMO h)* | p value | Amplitude (z-score) |
|---|---|---|---|---|
Zinc-alpha-2-glycoprotein (AZGP1) | P25311 | 4.4 | 0.009 | 0.28 |
Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) | P19823 | 10.0 | 0.019 | 0.30 |
Fibrinogen alpha chain (FGA) | P02671 | 7.9 | 0.019 | 0.30 |
Kininogen-1 (KNG1) | P01042 | 5.0 | 0.020 | 0.23 |
Apolipoprotein A-II (APOA2)r | P02652 | 10.1 | 0.021 | 0.27 |
Immunoglobulin kappa light chain (IGK) | P0DOX7 | 3.7 | 0.039 | 0.27 |
Plasminogen (PLG) | P00747 | 5.8 | 0.039 | 0.22 |
Immunoglobulin heavy constant mu (IGHM) | P01871 | 0.3 | 0.042 | 0.31 |
Immunoglobulin kappa constant (IGKC) | P01834 | 3.5 | 0.049 | 0.27 |
Protein (gene) with 24 hour rhythm | Uniprot ID | Acrophase (DLMO hr) | p-value | Amplitude (z-score) |
Plasminogen (PLG) | P00747 | -0.9 | 0.010 | 0.37 |
Apolipoprotein C-III (APOC3) | P02656 | 7.5 | 0.011 | 0.41 |
Fibrinogen alpha chain (FGA) | P02671 | -2.1 | 0.025 | 0.32 |
Fibrinogen beta chain (FGB) | P02675 | 0.0 | 0.034 | 0.31 |
Complement factor H (CFH) | P08603 | 0.2 | 0.042 | 0.29 |
Apolipoprotein E (APOE) | P02649 | 5.4 | 0.043 | 0.37 |
