Fig. 1: A schematic of our methodology highlighting strains of mice, light/dark (LD) cycles, and measurements.
From: Chronic circadian disruption alters cardiac function and glucose regulation in mice
B6 mice (top mouse) and BTBR mice (bottom mouse), display different endogenous periods in constant conditions (respective actograms). Each strain was bred in both LD cycles: one that matched and one that did not match their endogenous rhythm (LD = 24, LD = 22.74). Over the first six months of life, electrocardiograms were ran at one-, two-, and four-months-old. Mice were randomnly assigned to a GTT or ITT at three months old. At six months, they were perfused and hearts were collected for histology. Mouse graphic from https://creazilla.com/media/clipart/19072/lab-mouse used under CC0 1.0 licence.
