Fig. 5: Changes in metabolism in B6 and BTBR mice between LD cycles.
From: Chronic circadian disruption alters cardiac function and glucose regulation in mice
Blood glucose levels were measured and the area under the curve (AUC) was calculated and compared between groups following the GTT or the ITT. Male B6 mice had the largest area under the curve following administration of 2 kg/g of glucose (A; p < 0.001), and mismatched females had significantly larger AUCs than matched females (A; p < 0.01). Misaligned male BTBR mice had larger AUCs than females in a misaligned LD cycle following a glucose bolus (A; p < 0.01). B6 mice had slightly larger AUCs than BTBRs (B; p < 0.05) and males had larger AUCs that females (B; p < 0.001). Mismatched B6 and BTBR mice displayed larger AUCs following an injection of 0.75IU/kg of insulin compared to matched groups (B; p < 0.001). Error bars represent SEM.
