Fig. 2: The clock regulates cytoplasmic biomolecular condensates in animals and fungi.
From: Regulatory links between the circadian clock and stress-induced biomolecular condensates
A The clock regulates rhythmicity of the kinase (GCN2/CPC-3) that phosphorylates eIF2α (P-eIF2α)78,115. In fungi, rhythmic eIF2α phosphorylation inhibits translation initiation of certain mRNAs in a time-of-day dependent manner78. Inhibition of translation initiation by P-eIF2α promotes the sequestration of specific transcripts into cmRNPgs, such as PBs, which results in rhythmic translation74. B In mice, reduction in expression of the clock gene, BMAL1, increases the levels of P-eIF2α and results in more stress granules during the subjective night under sodium arsenite (SA) stress114. ZT0 - 24 indicates continuous light conditions, ZT (Zeitgeber). White rectangle on the graph represents the day and the gray rectangle represents the subjective night. Figure created in BioRender. Brown, G and Nagel, D. (2025) https://BioRender.com/snbvhrq.
