Table 1 Divergent Disorder-Specific Correlations Between Sleep Onset Microstructure and Macrostructure (pre-specified pairing).

From: Disordered descent into sleep: microstructural divergence across arousal-linked conditions

Disorder

Microstructural Metric

Macrostructural Feature

Δr

95% CI for Δr

Narcolepsy type 1

Stage-occupancy entropy (H4–H10)

Total sleep time (TST, min)

0.725

[0.027, 1.262]

  1. Pairings with REM% and N1% in NT1 showed similar directions but wider 95% CIs that included zero and are reported descriptively in the text.
  2. Bootstrapped comparisons of correlations (Δr) between key microstructural and macrostructural sleep features, in clinical groups versus their matched controls were undertaken. For the primary analyses, Δr was considered statistically significant if its bootstrapped 95% confidence interval excluded zero. However, all micro–macro correlation analyses reported here, including those in narcolepsy type 1, were pre-specified as exploratory in a small sample; accordingly, we treat these Δr estimates as descriptive and do not regard confidence intervals excluding zero as confirmatory evidence. The pre-specified pairing in NT1 was entropy (stage-occupancy) with total sleep time (TST).
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