Fig. 2: Effect of 12 weeks of GAN diet feeding on body weight, food intake, fat mass, metabolic and biochemical parameters in FGF21 KO rats.
From: FGF21 deletion mildly exacerbates hepatic dysfunction in GAN diet and alcohol fed rats
A Validation of circulating FGF21. B Body weight trajectories. C Food intake. D Terminal body weight. E 12-week body weight gain. F Terminal liver weight. G IWAT weight. H EWAT weight. I BAT weight. J 4 h fasted blood glucose. K 4 h fasted plasma insulin. L 4 h fasted plasma triglycerides. M 4 h fasted plasma total cholesterol. N 4 h fasted plasma ALT. O 4 h fasted plasma AST. P Liver triglyceriders. Q Liver total cholesterol. n = 7–16 rats/group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (A unpaired t-test; B, C two-way repeated measures ANOVA; D–S two-way ANOVA). GAN Gubra-Amylin MASH, WAT white adipose tissue, IWAT inguinal WAT, EWAT epididymal WAT, BAT brown adipose tissue, ALT alanine transaminase, AST aspartate transaminase.
