Fig. 3: Correlations between metabolites, proteomic analytes and clinical fatigue scores. | npj Metabolic Health and Disease

Fig. 3: Correlations between metabolites, proteomic analytes and clinical fatigue scores.

From: Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS

Fig. 3

Analyte-Symptom correlations. Heat maps showing correlations between significantly altered analytes and MFI symptom severity in ME/CFS (A) before and (B) after exercise, and in HC (C) before and (D) after exercise. Regularized canonical correlation analysis (RCCA) with Lasso penalty was used. Drug metabolites were excluded in this analysis. The full analyte-symptom correlation results are reported in Supplementary Data 9. Analyte-analyte correlations. Alluvial plots showing the spearman correlations, in ME/CFS and HC, separately, between plasma levels of metabolomic and proteomic analytes, which showed significant difference between ME/CFS and HC (E) before and (F) 24 h after exercise. Drug metabolites were excluded in this analysis. Clustering was performed using the Louvain Method and the module centers (or hubs) were identified based on eigenvector centrality scores.

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