Fig. 3: Illustration of cis-acting, trans-acting, and cis-position, trans-acting variants affecting the expression and function of a drug-targeting protein.
From: A translational framework of genoproteomic studies for cardiovascular drug discovery
Cis-acting variants, located within or near the protein-coding gene, directly influence the expression and function of the drug-targeting protein. In contrast, trans-acting variants (including cis-position, trans-acting variants), resided apart from the protein-coding gene, exert indirect effects, influencing the protein’s expression and function through processes such as RNA-level transcription and translation, post-translational modifications, and protein-protein interactions.
