Fig. 1: Results of the association between concomitant use of proton pump inhibitors and oral anticoagulants and gastrointestinal bleeding in cohort and case-crossover studies.

CPRD Clinical Practice Research Datalink, CDARS Clinical Data Analysis and Reporting System, CCO case-crossover, CI confidence interval, DOAC direct anticoagulant, PPI proton pump inhibitors. Note: The parameter without an eligible estimate was not shown in the figure which is because of an extremely small number of events. Point estimate refers to the hazard ratio for cohort study analysis and the odds ratio for case-crossover study analysis.