Fig. 1: scRNAseq of PBMCs post-MI.

A Identification of 10 cell populations. B Cell population proportions over time. C Differential gene expression of PBMCs showing that TIM-3, encoded by HAVCR2, was downregulated in PBMCs of patients with MI up to 8 weeks post-MI as compared to in PBMCs from the healthy controls (p-value < 0.05). D A temporal overview indicating that effector cells, CD4+ and CD8+ T cells as well as NK cells drove this decreased phenotype at 24 hours post-MI, and that all cells, except B-cells, downregulated TIM-3 gene expression after 8 weeks in patients with MI as compared to controls. MI Myocardial infarction; TIM-3 T-cell immunoglobulin and mucin-domain containing protein-3; PBMCs Peripheral blood mononuclear cells; NK Natural killer cells; DC Dendritic cells.