Fig. 5: Myocardial HMGB-1 expression in ischemic injury.
From: The immune checkpoint TIM-3/HMGB-1 axis in myocardial infarction
A Representative immunohistochemical staining of HMGB-1 on cardiac tissue from mice who underwent sham (n = 3) or MI (n = 3) surgery 6 weeks post-surgery and quantification. Scale is 2 mm. B Representative immunohistochemical staining of HMGB-1 in hearts of patients with ischemic injury compared to controls. Samples collected from explanted heart. White arrows indicate HMGB-1 expression; intranuclear in the left panel and translocated into the cytoplasm or extracellular space in the right. Scale is 100 µm. Data are mean ± SEM. COLOC Colocalization; HMGB-1 High mobility group box-1; MI Myocardial infarction.
