Table 1 Associations of circulating TIM-3 ligands with cardiac remodeling

From: The immune checkpoint TIM-3/HMGB-1 axis in myocardial infarction

 

Infarct size

LVEF

 

Univariate

Multivariate

Univariate

Multivariate

 

β

p-value

β

p-value

β

p-value

β

p-value

HMGB-1

-0.006

0.947

-

-

-0.210

0.026

-0.236

0.018

Gal-9

-0.258

0.006

-0.254

0.015

0.057

0.535

-

-

CEACAM1

0.036

0.696

-

-

-0.189

0.040

-0.105

0.251

  1. Linear and multivariate regression of HMGB-1, Gal-9, CEACAM1 at 24 h post-MI (quartile(Q) 4 vs Q1). Multivariate regression adjusted for age, sex, body mass index (BMI), hypercholesterolemia, Thrombolysis in Myocardial Infarction (TIMI) flow and myocardial blush grade. LVEF Left Ventricular Ejection Fraction; TIM-3 T-cell Immunoglobulin and Mucin-Domain Containing Protein-3; HMGB-1 High-Mobility group box 1; Gal-9 Galectin-9; CEACAM1 Carcinoembryonic-Antigen-related Cell-Adhesion Molecule 1.
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