Fig. 2: sdRT-QuIC and RT-QuICR analyses of intestinal mucosa (IM) biopsies.
From: A same day α-synuclein RT-QuIC seed amplification assay for synucleinopathy biospecimens
a Representative end-point dilution analysis of a PD and an NS control IM sample. Data points indicate means ± SD of quadruplicate reactions at the designated dilutions of PD (n = 1) and control IMs (n = 1). b 1/time to threshold and c ThT maxima obtained from 10-3 dilutions of PD (n = 23) and NS (n = 6) IMs. d 1/TTT at 10−3 dilution of the same panel of PD and NS IMs using the RT-QuICR assay (data summarized from Fig. 3 of ref. 27). In b–d, data points represent means of quadruplicate reactions from individual cases, and bars represent the mean ± SD of the means from all cases. The same IM specimens were used in the RT-QuICR and sdRT-QuIC assays. Statistical significance is denoted as *p < 0.05, **p < 0.01, ***p < 0.001.
