Fig. 2: Various solvent conditions promoting amyloid formation.
From: Mechanism of amyloid fibril formation triggered by breakdown of supersaturation
Macromolecular crowding and solvation effects modulate the solute concentration and solubility, respectively, through distinct mechanisms, which lead to amyloid formation after breaking supersaturation. The same mechanism may work adversely on folded proteins, stabilizing the native state and possibly native-state crystallization.
