Fig. 5: Monitoring cell coverage and therapeutic response of MCF-7 cells.
From: Incubator-integrated electrochemical analysis platform for cell-based studies
A The schematic illustration of the PTX mechanism. Created with BioRender.com. B EIS, C CV, and D DPV results for the SPEs seeded with MCF-7 cells of different densities. Orange: No cell, gray: 2.5 × 105 cells/mL, black: 5 × 105 cells/mL, red: 7.5 × 105 cells/mL, blue: 1 × 106 cells/mL, and green: 2 × 106 cells/mL. For the EIS spectra, the figure inset zooms into a small Re[Z] range displaying the impedance behavior of the cell-free SPE (orange), and the SPE seeded with 2.5 × 105 cells/mL (gray), and 5 × 105 cells/mL (black) densities. E EIS, F CV, and G DPV results for the SPE seeded with MCF-7 cells of 5 × 105 cells/mL density under different PTX concentrations, e.g., 1 nM (red), 5 nM (blue), and 50 nM (green) with the control group (black). Figure 4E-inset shows the equivalent circuit model used to fit the EIS data.
