Table 1 Comparison of typical sensor architectures

From: Surface Transmon Resonance (STR): a handheld nanogap biosensor for real-time, label-free molecular binding kinetics

 

SPR (gold standard)

STR (this work)

ISFET

EIS

Debye Screening Limited

Optical sensor, not affected

No (High-frequency operation, >100 MHz)

Yes

Somewhat (0 Hz– 1 MHz)

Real-Time Kinetics

Yes

Yes (phase-resolved)

Limited (drift-sensitive, poor S/N)

Limited (slow freq sweep)

Portability

No

Yes

Yes

Yes

Cost

$100,00–$500,000

$300

$500–$2,000

$5000–$25,000