Fig. 5: Diagram of the 8-dimensional biological network featuring the senescence marker P53. | npj Biological Physics and Mechanics

Fig. 5: Diagram of the 8-dimensional biological network featuring the senescence marker P53.

From: Unifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasets

Fig. 5

Schematics of the 8-dimensional biological network involving the senescence marker P53. a The examined proteome of the P53 network. The input data are expressions of the 8 molecules measured in the single cell experiment and the output is the P53 expression. The probability distribution of all variables are show in 4 different cell conditions: 1. control; 2. quiescent; 3. treated with 50 μM Bleomycin; 4. treated with 200 nM doxorubicin. Cells in different conditions show different proteome distributions because they have different cell cycle distributions. b Joint probability distribution of Dapi and LaminB1 for senescent cells treated with 50 μM Bleomycin. c Joint probability distribution of Dapi and LaminB1 for standardized data of senescent cells treated with 50 μM Bleomycin. The contour lines are from the Gaussian mixture model used to describe the probability distribution.

Back to article page