Fig. 2: Expression of organ-tropic genes is altered when cell mechanics are altered.
From: Premetastatic niche mechanics and organotropism in breast cancer
mRNA expression of canonical bone-metastasis genes (left) and brain-metastasis genes (right) in MDA-MB-231 bone-tropic subline after (a) pharmacologically disrupting cell mechanics (24 hours) or (b) knocking down mDia1, a downstream effector of RhoA and key driver for actin polymerization. Y27632 is a ROCK inhibitor; Cytochalasin D (Cyto D) is an F-actin inhibitor, and Blebbistatin is a myosin II inhibitor. Values measured by real time-polymerase chain reaction (RT-PCR). *: p < 0.05; **: p < 0.01; and *** p: < 0.001. Figure adapted from Tang et al.78 under CC BY 4.0.
