Table 1 Total number (top) and percentage (bottom) of patients with single site metastasis to bone, liver, lung, or brain, segmented by breast cancer subtype

From: Premetastatic niche mechanics and organotropism in breast cancer

 

Single Site Metastasis

 

Bone

Liver

Lung

Brain

Luminal A HR + /HER2-

2144

178

194

69

335

85

27

6

79.4%

52.7%

7.2%

20.4%

12.4%

25.1%

1.0%

1.8%

Luminal B HR + /HER2+

304

452

113

265

63

299

7

32

62.4%

43.1%

23.2%

25.3%

12.9%

28.5%

1.4%

3.1%

HR-/HER2+

112

150

131

148

80

189

14

20

33.2%

29.6%

38.9%

29.2%

23.7%

37.3%

4.2%

3.9%

Triple-Negative

243

155

106

87

257

156

35

23

37.9%

36.8%

16.5%

20.7%

40.1%

37.1%

5.5%

5.5%

  1. Number of patients were obtained from Guo et al.64 (left of each metastatic location column) and Fan et al.65 (right of each metastatic location column)
  2. Percentage was recalculated here, to determine the percent of patients within each subtype that presented with a particular single site metastatic location, for better comparison between studies. Percentages in left or right) columns add to 100% within each subtype row, with rounding tolerance. Abbreviations: HR (Hormone Receptor). The hormones referred to are estrogen and progesterone. HER2 (Human Epidermal Growth Factor Receptor 2).