Fig. 2: Phenotypic sensitivity to change in substrate conditions.
From: Tissue-dependent mechanosensing by cells derived from human tumors
For each cell line, the ratio of the median values for a cell area, b cell stiffness, and c cell speed as a measure of the phenotypic sensitivity to substrate change. (30k–500 Pa Coll: 30 kPa Coll/500 Pa Coll, 30k-500Pa FN: 30 kPa FN/500 Pa FN, HA-500Pa Coll: HA Coll/500 Pa Coll, HA-500Pa FN: HA FN/500 Pa FN). (N) refers to non-malignant (normal) cell lines. See also Supplementary Figs. 2–5. ***p < 0.01; **p < 0.05; *p < 0.1, adjusted for multiple testing using Benjamini-Hochberg procedure. For each cell line, phenotypic sensitivity to substrate change is calculated only if there are at least 25 data points (n ≥ 25) for the physical feature of interest on both the substrates. See Supplementary Tables 1–3 for the exact value of n for the cell lines.
