Fig. 3: Synthetic scheme and structure activity of novel sCLU enhancers. | npj Drug Discovery

Fig. 3: Synthetic scheme and structure activity of novel sCLU enhancers.

From: Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer’s disease mice

Fig. 3

A General synthetic scheme used for the synthesis of ester-containing (+)-JQ1 analogs, and the biological activity (sCLU EC50, BRD2/4 IC50) for ester-containing analogs, DDL-351, -355, -356, -357, and -358. B General synthetic scheme used for the synthesis of amide-containing (+)-JQ1 analogs, and the biological activity (sCLU EC50, BRD2/4 IC50) for amide-containing analogs DDL DDL-352, -353, -354, -359, and -360. Four analogs had increased potency for sCLU enhancement, relative to (+)-JQ-1.

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