Table 3 (A) Model 1 results on the regression of smoking pack years against brain volumes, adjusting for age, sex, and study site and (B) Model 2 results on the regression of smoking pack years against brain volumes, adjusting for age, sex, and BMI
Brain region | Standardized β coefficient (standard error) | T-statistic (p valuea) | R2 | Adjusted R2 |
|---|---|---|---|---|
A | ||||
Gray Matter | −2.948e-04 (4.233e-05) | −6.963 (3.645e-12) | 7.045e-03 | 6.900e-03 |
White Matter | −3.049e-04 (4.218e-05) | −7.228 (5.441e-13) | 7.587e-03 | 7.442e-03 |
Lateral Ventricle | −1.053e-05 (6.179e-06) | −1.704 (8.844e-02) | 4.247e-04 | 2.784e-04 |
Frontal Lobe | −9.153e-05 (1.233e-05) | −7.424 (1.275e-13) | 8.002e-03 | 7.856e-03 |
Temporal Lobe | −6.680e-05 (9.292e-06) | −7.189 (7.201e-13) | 7.508e-03 | 7.362e-03 |
Parietal Lobe | −5.128e-05 (8.733e-06) | −5.872 (4.498e-09) | 5.021e-03 | 4.876e-03 |
Occipital Lobe | −2.026e-05 (4.464e-06) | −4.538 (5.782e-06) | 3.004e-03 | 2.859e-03 |
Hippocampus | −4.722e-06 (7.358e-07) | −6.418 (1.476e-10) | 5.991e-03 | 5.846e-03 |
Cerebellum | −6.750e-05 (1.213e-05) | −5.567 (2.695e-08) | 4.515e-03 | 4.369e-03 |
Posterior Cingulate | −4.261e-06 (5.780e-07) | −7.372 (1.883e-13) | 7.890e-03 | 7.745e-03 |
Precuneus | −6.618e-06 (1.687e-06) | −3.923 (8.845e-05) | 2.247e-03 | 2.101e-03 |
B | ||||
Gray Matter | −2.110e-04 (4.025e-05) | −5.242 (1.633e-07) | 4.006e-03 | 3.860e-03 |
White Matter | −2.288e-04 (4.048e-05) | −5.653 (1.639e-08) | 4.655e-03 | 4.510e-03 |
Lateral Ventricle | −7.494e-06 (6.160e-06) | −1.217 (2.238e-01) | 2.166e-04 | 7.024e-05 |
Frontal Lobe | −6.797e-05 (1.177e-05) | −5.777e (7.959e-09) | 4.860e-03 | 4.714e-03 |
Temporal Lobe | −4.851e-05 (8.840e-06) | −5.487 (4.226e-08) | 4.387e-03 | 4.242e-03 |
Parietal Lobe | −3.577e-05 (8.387e-06) | −4.264 (2.033e-05) | 2.654e-03 | 2.508e-03 |
Occipital Lobe | −1.240e-05 (4.289e-06) | −2.890e (3.863e-03) | 1.221e-03 | 1.075e-03 |
Hippocampus | −3.441e-06 (7.080e-07) | −4.860 (1.201e-06) | 3.445e-03 | 3.299e-03 |
Cerebellum | −4.602e-05 (1.165e-05) | −3.951 (7.869e-05) | 2.279e-03 | 2.133e-03 |
Posterior Cingulate | −3.249e-06 (5.560e-07) | −5.842 (5.380e-09) | 4.971e-03 | 4.825e-03 |
Precuneus | −4.091e-06 (1.640e-06) | −2.495 (1.262e-02) | 9.101e-04 | 7.639e-04 |
