Fig. 3: Path models showing direct, indirect and total associations betweenaccumulation of affective symptoms and cognitive measures via rateof telomere shortening.

a Unadjusted model (n = 1770). b Adjusted model (n = 1019). Covariances were included between cognitive measures andbetween each cognitive measure and affective symptoms age 69. Significant pathways are represented with solid arrows.Nonsignificant pathways are represented by dotted arrows.