Table 2 The Definitions of the Low- and High-risk R2 grade based on ETDRS studies.

From: Updates in the English Diabetic Eye Screening Programme

Lower risk (R2 L) is defined as the presence of ANY of the following features:

• 8 or more blot haemorrhages across the two digital 45 ° photographs

• More than 20 intraretinal haemorrhages or microaneurysms located in 1,2 or 3 (but not all 4) of the four quadrants of the retina

• Venous beading in 1 quadrant

• Any quantity of IRMA less than ETDRS Standard photograph 8a* (see image below)

Higher risk (R2H) is defined as the presence of ANY of the following features: 4-2-1 rule

• More than 20 intraretinal haemorrhages or microaneurysms in EACH of the four quadrants of the retina (see image below).

• Venous beading present in two or more quadrants

• Moderate IRMA equal to or worse than the Airlie House ETDRS Standard photograph 8a in one or more quadrants*

Please see Fig. 1 for examples of images.

* ETDRS Standard photograph 8a standard photograph shows multiple patches of moderate IRMA, and it is the severity and quantity of IRMA present within 1 quadrant that should be assessed to determine if there are equal to or greater levels of IRMA present within 1 quadrant. Only IRMAs that are definitely seen on colour imaging should be classified as R2.