Abstract
A patient with progressive spinal stenosis, paraplegia, chronic pain syndrome and simultaneous severe chronic constipation is described. Treatment with cisapride 10 mg, 4 times daily improved her condition, and this was associated with improved small intestinal motility during a 12-hour examination using a computer aided system.
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References
Altaparmakov I 1985 Non-cholinergic stimulation of contractile activity of human colon by a novel gastrointestinal prokinetik cisapride. Naunyn-Schmiedeberg's Archives of Pharmacology 330 (Supplement): R77.
Camilleri M, Brown M L Malagelada J-R 1986 Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. Gastroenterology 91: 619–626.
Coremans G, Chaussade S, Janssens J, Vantrappen G, Ceccatelli P 1985 Stimulation of propulsive motility patterns by cisapride in the upper gut in man. Digestive Diseases and Sciences 30: 765.
Edwards C A, Holden S, Brown C, Read N W 1987 Effect of cisapride on the gastrointestinal transit of a solid meal in normal subjects. Gut 28: 13–16.
Lee K Y, Chey W Y, You C H, Shah A N, Hamilton D 1984 Effect of cisapride on the motility of gut in dogs and colonic transit time in dogs and humans. Gastroenterology 86: 1157.
Schemann M, Ehrlein H 1984 Cisapride stimulates peristaltic activity of the canine jejunum during the digestive period. Gut 25: 1310A.
Schuurkes J A J, Verlinden M, Akkermans L M A, Van Nueten J M 1983 Stimulating effects of R 51 619 on antroduodenal motility in the conscious dog. Gastroenterologic Clinique et Biologique 7: 704.
Stacher G, Steinringer H, Schneider C, Winklehner S, Mittelbach G, Gaupmann G 1986 Effects of cisapride on jejunal motor activity in fasting healthy humans. Gastroenterology 90: 1210–1216.
Stacher G, Gaupmann G, Mittelbach G, Schneider C, Steinringer H, Langer B 1987 Effects of oral cisapride on interdigestive jejunal motor activity, psychomotor function, and side-effect profile in healthy man. Digestive Diseases and Sciences 32: 1223–1230.
Vantrappen G, Janssens J, Hellemans J, Ghoos Y 1977 The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. Journal of Clinical Investigation 59: 1158–1166.
Van W yk M, De Sommers K, Steyn A G W 1985 Evaluation of gastro-intestinal motility using the hydrogen breath test. British Journal of Clinical Pharmacology 20: 479–181.
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Hellström, P., Aly, A. & Johansson, C. Cisapride stimulates small intestinal motility and relieves constipation in myelopathy due to cervical spinal stenosis: case report. Spinal Cord 28, 261–264 (1990). https://doi.org/10.1038/sc.1990.33
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DOI: https://doi.org/10.1038/sc.1990.33