Abstract
The rheumatoid factor (RF) levels of IgM-RF and IgG-RF types in sera from patients with spinal cord injuries (SCI) and osteochondrosis were investigated by ELISA. According to the findings in the late stages of the disease, SCI patients showed 46% seropositiveness for IgG-RF and 40% for IgM-RF. Patients with fresh central nervous system (CNS) injuries were 12% and 14% seropositive, respectively. Patients with osteochondrosis exhibited 33% seropositiveness for IgG-RF. The determination of serum RF enables us to identify the systemic body lesion in the SCI late stages as a rheumatoid disease. These data support the conclusion that RF determination is a reliable serological indicator of the severity of a patient's traumatic disease.
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References
Detlav I E (1976) Antibrain antibodies in the blood serum and CSF following brain trauma. Zhurnal Nevropatologii i psikhiatrii im. S. S. Korsakova 26(3): 344–348. Voprosy Nejrokhirurgii 5: 32–35.
Kogan O G, Knyazhev V A, Belyaev A F (1981) Some parameters of specific humoral immunity in patients with trauma to the spinal cord. Voprosy Kurortologii, Fisyoterapii i Lechebnoj Fiskultury 4: 55–58.
Zborobsky A B, Lempert B A, Yugtina M E (1989) Clinical and diagnostic significance of rheumatoid factors of various classes in rheumatoid arthrits. Sovetskaya meditsina 12: 6–9.
Ponomaryova A M, Denisova O V, Popkov M Y u, Alyoshkin V A (1989) Identification of IgG rheumatoid factor in reumatoid arthrits by enzyme immunology. Immunologiya 3: 89–91.
Palosuo T, Aho K (1983) Technical falsely positive reumatoid factor by ELISA in sera with elevated IgM levels. Med Biol 61: 203–207.
Nasonova V A, Astapenko M G (1989) Clinical Rheumatology. Meditsina, Moscow.
Leonovich A L (1990) Actual Questions of Neuropathology. Vysshaya shkola, Minsk.
Yekutiel M, Brooks M E, Ohry A, Yarom J, Carel R (1989) The prevalence of hypertension ischaemia heart disease and diabetes in traumatic spinal cord injured patients and amputees. Paraplegia 27: 58–62.
Tupikin G V, Kogan B M, Kuzmishin L S, Sokolova D A, Redina T A (1984) Diagnosis of cardiovascular disorders in rheumatoid arthritis patients. Reumatologiya 2: 22–25.
Pope R M, McDuffy S I (1979) IgG rheumatoid factor. Relationship to seropositive rheumatoid arthritis and absence in seronegative disorders. Arthritis Rheum 22: 988–998.
Withrington R H, Teitsson J, Valdimarsson H, Scifert M H (1984) Prospective study of early rheumatoid arthritis. II Association of rheumatoid factor isotypes with fluctuations in disease activity. Ann Rheum Dis 43: 679–685.
Zlabinger G J, Haberhauer G, Dax K, Menzel E J, Bröil H (1990) Rheumatoid factor isotypes and circulating immune complexes in rheumatoid arthritis. Clin Exp Immunol 8: 113–119.
Malashkhiya Yu A, Geladze M G, Lomdzhariya L D, Mikeladze N A (1982) Cerebrospinal fluid as the immunological barrier of the brain. Immunologia 6: 76–78.
Pobedina V G, Geilfand V B (1977) Functional activity of blood leukocytes in traumatic lesion of spinal cord. Zhurnal Voprosy Neirokhirurgii im. N. N. Burdenko iss. 5, 25–28.
Yumashev G S, Petrova N V, Eliseyev A T, Alyoshkin V A, Rozina M N (1991) Immune complexes of blood and liquor of patients with trauma of spinal cord. Klinicheskaya Meditsina 3: 56–58.
Gannushkina I V (1974) Immunological aspects of brain injury and cerebral vascular disturbances. Meditsina, Moscow: 199.
Pope R M, Yoshinoya S, McDuffy S I (1981) Detection of immune complexes and their relationship to rheumatoid factor in a variety of autoimmune disorders. Clin Exp Immunol 46: 259–267.
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Petrova, N., Ponomaryova, A., Alyoshkin, V. et al. Serum rheumatoid factors in spinal cord injury patients. Spinal Cord 31, 265–268 (1993). https://doi.org/10.1038/sc.1993.47
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DOI: https://doi.org/10.1038/sc.1993.47