Abstract
Study design:
Laboratory investigation in rats submitted to experimental spinal cord injury (SCI).
Objective:
To characterize changes in renal function during acute SCI.
Methods:
Sprague Dawley rats were subjected to severe spinal cord contusion at T8 level or to laminectomy as control. Twenty-four hours after spine surgery, clearance assessments of a single dose of iohexol (120 mg kg−1) or of p-aminohippuric acid (PAH, 100 mg kg−1) were used to evaluate glomerular filtration rate (GFR) and tubular secretion (TS), respectively. Blood sampling was used to determine concentrations of both compounds by high-performance liquid chromatography for pharmacokinetic measurements.
Results:
Iohexol clearance decreased significantly after injury, which resulted in increased concentrations and half-life of iohexol in blood; PAH clearance remained unchanged.
Conclusion:
GFR but not TS is altered during spinal shock. These observations should be of interest to professionals caring for early cord-injured patients, in order to prevent toxicity and therapeutic failure when administering drugs eliminated by the kidney.
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Rodríguez-Romero, V., Cruz-Antonio, L., Franco-Bourland, R. et al. Changes in renal function during acute spinal cord injury: implications for pharmacotherapy. Spinal Cord 51, 528–531 (2013). https://doi.org/10.1038/sc.2013.35
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DOI: https://doi.org/10.1038/sc.2013.35
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