Abstract
Study design:
Case series.
Objectives:
To investigate the effects of wheelchair basketball game on plasma interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and blood cell counts in persons with spinal cord injury (SCI).
Setting:
The 2009 Mei-shin League of Wheelchair Basketball Games held at Wakayama, Japan.
Participants:
Five wheelchair basketball players with SCI voluntarily participated in this study.
Interventions:
Blood samples were taken approximately 1 h before the player warm-up for the game and immediately after the game.
Main outcome measures:
IL-6, TNF-α, CRP and blood cell count were measured.
Results:
Plasma IL-6 level and number of monocytes were significantly increased after the game, compared with pre-game measurements (P<0.05). No changes were observed in other measurements. There was a significant relationship between increased IL-6 levels and accumulated play duration.
Conclusion:
The lack of change in TNF-α and CRP levels suggested that the exercise-induced rise in IL-6 was not related to exercise-induced inflammatory response. Furthermore, the associated increase in the number of monocytes did not correlate with exercise-induced IL-6 changes, negating monocytes as the source of IL-6.
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Acknowledgements
We thank Drs Midori Yamanaka, Yusuke Sasaki and Ken Kouda for the clinical assistance. We also thank Dr Faiq G Issa (www.word-medex.com.au) for the careful reading and editing of the manuscript.
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Kinoshita, T., Nakamura, T., Umemoto, Y. et al. Increase in interleukin-6 immediately after wheelchair basketball games in persons with spinal cord injury: preliminary report. Spinal Cord 51, 508–510 (2013). https://doi.org/10.1038/sc.2013.4
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DOI: https://doi.org/10.1038/sc.2013.4
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