Figure 2
From: MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury
Progressive expansion of hemorrhagic contusion assessed from tissue sections at the epicenter. (a) Representative coronal tissue sections of perfusion-cleared but otherwise unprocessed spinal cords through the epicenter of injury 15 min (top) and 24 h (middle and bottom) after impact, in control rats (top and middle), and in a glibenclamide-treated rat (bottom); the data shown are representative of eight rats per group. (b): Fold-change in areas of hemorrhage at the epicenter in the three groups of rats depicted in (a); mean±s.e.; eight rats per group; ***P<0.001. (c) Box plots showing modified (unilateral) BBB scores for the ipsilateral and contralateral hindlimbs at 24 h, for the two groups of rats depicted in (b, 24 h Veh and 24 h Glib); box, 25th and 75th percentiles; × , 1st and 99th percentiles; line, median; small square, mean.
