Abstract
Study design:
A cross-sectional observational study was conducted.
Objective:
The aim was to analyze the clinical–functional profile of patients diagnosed with HTLV-1 (human T-lymphotropic virus type 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in the Amazon region.
Setting:
Reference center for HTLV in the city of Belém, state of Pará, Brazil.
Methods:
Muscle strength, muscle tone, balance and the need for gait assistance among patients with HAM/TSP were evaluated.
Results:
Among the 82 patients infected with HTLV-1, 27 (10 men and 17 women) were diagnosed with HAM/TSP. No statistically significant difference in muscle tone or strength was found between the lower limbs. Muscle weakness and spasticity were predominant in the proximal lower limbs. Patients with HAM/TSP are at a high risk of falls (P=0.03), and predominantly use either a cane or a crutch on one side as a gait-assistance device (P=0.02).
Conclusion:
Patients with HAM/TSP exhibit a similar clinical pattern of muscle weakness and spasticity, with a high risk of falls, requiring gait-assistance devices.
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Dias, G., Yoshikawa, G., Koyama, R. et al. Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. Spinal Cord 54, 154–157 (2016). https://doi.org/10.1038/sc.2015.112
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DOI: https://doi.org/10.1038/sc.2015.112
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