Abstract
Study design:
Experimental study.
Objectives:
To study the role of surface temperature as an adjunct to motor evoked potentials (MEPs) in rabbit spinal cord injury (SCI) model.
Setting:
Department of Orthopedics, Korea University Guro Hospital, Seoul, Korea.
Methods:
Rabbits (n=18) were divided into Complete (n=9) and Incomplete (n=9) SCI groups. Complete SCI was defined as being non-responsive to a wake-up test with loss of MEPs after transection of spinal cord. Incomplete SCI was defined as being responsive to a wake-up test with significant attenuation (⩾80%) of MEPs after impaction on spinal cord. Surface temperature of upper and lower extremities, core temperature and MEPs signals were checked before, during and after SCI for 20 min. A wake-up test was conducted and spinal cord was histologicaly evaluated.
Results:
Experimental conditions between the two groups were statistically similar (P>0.005 for all values). After SCI, upper extremity temperatures did not change in either group (P>0.005); however, the surface temperature of the lower extremities in the Complete SCI Group elevated to 1.7±0.5 °C in comparison to 0.5±0.1 °C in the Incomplete SCI Group (P<0.001). The scores of wake-up test in the Incomplete SCI Group were significantly different from that of the Complete SCI Group (P<0.001), while white and gray matter damage was variable on histology.
Conclusions:
Monitoring of changes of body surface temperature of the lower extremities can be potentially used to identify the completeness of SCI in a rabbit model.
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Acknowledgements
This study was supported by a grant of the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI11C0388). This study was performed under the approval of the IACUC (Institutional Animal Care and Use Committee, KU12129). All experimental procedures, protocols and treatment of experimental animals were performed under the control of the IACUC. This study was performed in the Korea University Guro Hospital.
Author contributions
SWS carried out the arrangement of the enrolled patients and drafted the manuscript as an assistant of JHY. YSP participated in the design of the study and performed the statistical analysis as an assistant of JHY. SWS carried out the arrangement of the enrolled patients and drafted the manuscript as an assistant of JHY. J-HL and BKP participated in the design of the study. CHH participated in the design and revision work of the study. JHY participated in the design of the study, statistical analysis and coordination, and drafted the manuscript as the main author. All authors read and approved the final manuscript.
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Yang, J., Suh, S., Park, YS. et al. Change in body surface temperature as an ancillary measurement to motor evoked potentials. Spinal Cord 53, 827–834 (2015). https://doi.org/10.1038/sc.2015.90
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DOI: https://doi.org/10.1038/sc.2015.90
