Figure 3: Demonstration of methylation hits compared to a new methylation value system.
From: DNA methylation temporal profiling following peripheral versus central nervous system axotomy
(a) Legend for defined Methylation Values (MV) and schematic for semi-quantitative analysis of the DNA methylation microarray dataset. Arbitrary MV were defined according to the ranking of calculated differences (DMV) between relative injury and sham hit numbers (see Text) in order to determine genes with strong, medium, or weak hyper- and hypomethylation for each condition (with respect to naive being similar to sham). (b) Selected differentially hyper- or hypomethylated genes are visualized as an example of filtering genes applying the supplemented interactive NimbleGen analysis table. These genes exhibit a different injury-induced promoter methylation state only upon one injury type while not changing upon the other, regarding combined injury (Inj) and sham (Sh) for each condition.
