Table 2 Biomarkers of exposure—Carboxyhemoglobin (COHb) concentration (%), nicotine and cotinine concentrations in plasma (mean±s.e.m.)
From: Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice
Parameter | Month | Sham | 3R4F | pMRTP | Cessation | Switch |
|---|---|---|---|---|---|---|
COHb (%) | 3 | 4.3±0.5 | 22.0±3.8 | 10.2±1.3 | 4.4±0.5 | 11.2±2.1 |
4 | 4.9±0.6 | 28.3±5.3 | 10.6±0.8 | 5.6±0.5 | 13.2±1.1 | |
6 | 4.9±0.4 | 34.5±7.8 | 9.5±1.5 | 4.9±0.4 | 11.1±1.9 | |
Nicotine (ng/ml) in plasma | 7 | 1.6±0.5 | 6.4±0.5 | 3.9±0.4 | 1.7±0.6 | 7.1±2.1 |
Cotinine (ng/ml) in plasma | 7 | <LOD | 35.7±6.4 | 31.1±4.4 | <LOD | 49.5±9.5 |
Trans-3'-Hydroxycotinine in urine (μmol/l) | 6 | <LOQ | 102±9.8 | 75.7±9.4 | <LOQ | 60.0±5.3 |
Norcotinine in urine (μmol/l) | 6 | 0.7±0.1 | 123± 17 | 123± 17 | 0.9±0.1 | 104±8.3 |
Cotinine in urine (μmol/l) | 6 | <LOQ | 20.0±2.8 | 10.5±0.9 | <LOQ | <LOQ |
Nicotine-N'-oxide in urine (μmol/l) | 6 | <LOQ | 39.3±6.8 | 39.3±6.8 | <LOQ | 29.1±3.0 |
Nornicotine in urine (μmol/l) | 6 | <LOQ | 23.2±3.7 | 16.1±1.4 | <LOQ | 15.0±1.6 |
