Figure 4: Quality metrics used for sample filtering. A three-part quality control pipeline was used to identify samples with low quality.

(a) The distribution of mean detection p-values for all probes in each sample. (b) The distribution of the number of probes with missing data per sample. (c) The distribution of the top 25 probes with missing data. For panels a and b, colors represented BM subtype with green bars representing breast cancer brain metastases (BCBM), orange bars representing lung cancer brain metastases (LCBM), and purple bars representing melanoma brain metastases (MBM).