Table 2 ISA-tab formatted table for the access of genome-wide DNA methylation and clinical-demographic data for each patient in the study

From: Brain metastasis DNA methylomes, a novel resource for the identification of biological and clinical features

Sample Name

Source name

Characteristics[organism]

Characteristics[organism part]

Characteristics[sample type]

Method [Protocol 1]

Method [Protocol 2]

Method [Protocol 3]

Method [Protocol 4]

Method [Protocol 5]

Factor Value [Age at BM diagnosis (years)]

Factor Value [Gender]

Factor Value [Primary Cancer Origin]

Factor Value [BM Cancer Specific Subtypes]

Days to Last Follow-up or Death

Overall Survival Status

Assay Name

Raw or Derived Data File [IDAT file 1]

Raw or Derived Data File [IDAT file 2]

Data Repository

Data Record Accession [GEO Serie]

Data Record Accession

BCBM-01

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

43

Female

Breast Cancer

HER2 positive/HR any

3179

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R06C02_Grn.idat

200397860045_R06C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905348

BCBM-02

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

51

Female

Breast Cancer

HER2 positive/HR any

1296

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R01C01_Grn.idat

200770460177_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905349

BCBM-03

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

52

Female

Breast Cancer

Hormone receptor positive/HER2 negative

6849

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R06C01_Grn.idat

200123460166_R06C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905350

BCBM-04

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

52

Female

Breast Cancer

Hormone receptor positive/HER2 negative

6849

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R01C02_Grn.idat

200123460166_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905351

BCBM-05

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

53

Female

Breast Cancer

HER2 positive/HR any

1529

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R02C02_Grn.idat

200397860045_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905352

BCBM-06

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

62

Female

Breast Cancer

HER2 positive/HR any

5643

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R02C01_Grn.idat

200770460177_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905353

BCBM-07

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

79

Female

Breast Cancer

Triple Negative Breast Cancer

1328

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R05C02_Grn.idat

200397860045_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905354

BCBM-08

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

50

Female

Breast Cancer

HER2 positive/HR any

4777

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R02C02_Grn.idat

200123460166_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905355

BCBM-09

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

73

Female

Breast Cancer

Triple Negative Breast Cancer

18240

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R03C02_Grn.idat

200123460166_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905356

BCBM-10

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

77

Female

Breast Cancer

Hormone receptor positive/HER2 negative

1324

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R01C01_Grn.idat

200123460166_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905357

BCBM-11

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

40

Female

Breast Cancer

Triple Negative Breast Cancer

907

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R02C01_Grn.idat

200123460166_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905358

BCBM-12

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

50

Female

Breast Cancer

HER2 positive/HR any

989

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460041_R02C01_Grn.idat

200770460041_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905359

BCBM-13

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

56

Female

Breast Cancer

Triple Negative Breast Cancer

3724

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R03C01_Grn.idat

200123460166_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905360

BCBM-14

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

44

Female

Breast Cancer

Hormone receptor positive/HER2 negative

2075

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R04C01_Grn.idat

200123460166_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905361

BCBM-15

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

65

Female

Breast Cancer

Hormone receptor positive/HER2 negative

2511

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200123460166_R05C01_Grn.idat

200123460166_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905362

BCBM-16

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

72

Female

Breast Cancer

Hormone receptor positive/HER2 negative

2239

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460041_R01C01_Grn.idat

200770460041_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905363

BCBM-17

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

40

Female

Breast Cancer

Hormone receptor positive/HER2 negative

1303

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460041_R03C01_Grn.idat

200770460041_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905364

BCBM-19

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

53

Female

Breast Cancer

HER2 positive/HR any

1529

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R03C02_Grn.idat

200397860045_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905365

BCBM-20

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

57

Female

Breast Cancer

HER2 positive/HR any

1084

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R01C01_Grn.idat

200770460180_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905366

BCBM-21

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

46

Female

Breast Cancer

Hormone receptor positive/HER2 negative

1905

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R02C01_Grn.idat

200770460180_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905367

BCBM-22

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

69

Female

Breast Cancer

Hormone receptor positive/HER2 negative

4554

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R03C01_Grn.idat

200770460180_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905368

BCBM-23

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

46

Female

Breast Cancer

Hormone receptor positive/HER2 negative

4357

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R04C01_Grn.idat

200770460180_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905369

BCBM-24

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

71

Female

Breast Cancer

HER2 positive/HR any

4737

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R05C01_Grn.idat

200770460180_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905370

BCBM-25

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

67

Female

Breast Cancer

Hormone receptor positive/HER2 negative

5125

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R06C01_Grn.idat

200770460180_R06C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905371

BCBM-26

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

57

Female

Breast Cancer

Triple Negative Breast Cancer

1883

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R01C02_Grn.idat

200770460180_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905372

BCBM-27

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

61

Female

Breast Cancer

Hormone receptor positive/HER2 negative

9131

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R02C02_Grn.idat

200770460180_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905373

BCBM-28

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

65

Female

Breast Cancer

Hormone receptor positive/HER2 negative

9131

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R03C02_Grn.idat

200770460180_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905374

BCBM-31

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

35

Female

Breast Cancer

HER2 positive/HR any

N/A

N/A

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R06C02_Grn.idat

200770460180_R06C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905375

BCBM-32

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

45

Female

Breast Cancer

HER2 positive/HR any

N/A

N/A

Illumina Infinium 450K Human DNA methylation Beadchip

201031670094_R04C01_Grn.idat

201031670094_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905376

BCBM-33

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

40

Female

Breast Cancer

HER2 positive/HR any

935

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R03C01_Grn.idat

200770460177_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905377

BM-01

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

58

Female

Lung Cancer

Non-Small Cell Lung Cancer

1642

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R04C02_Grn.idat

200770460180_R04C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905378

BM-02

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

68

Female

Lung Cancer

Non-Small Cell Lung Cancer

N/A

N/A

Illumina Infinium 450K Human DNA methylation Beadchip

200770460180_R05C02_Grn.idat

200770460180_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905379

BM-03

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

80

Female

Lung Cancer

Non-Small Cell Lung Cancer

1752

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R01C01_Grn.idat

200866140110_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905380

BM-04

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

55

Female

Lung Cancer

Non-Small Cell Lung Cancer

736

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R03C02_Grn.idat

200770460177_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905381

LCBM-01

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

62

Female

Lung Cancer

Non-Small Cell Lung Cancer

1551

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R04C01_Grn.idat

200770460177_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905382

LCBM-02

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

65

Female

Lung Cancer

Non-Small Cell Lung Cancer

1074

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R05C01_Grn.idat

200770460177_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905383

LCBM-03

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

74

Female

Lung Cancer

Non-Small Cell Lung Cancer

703

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R06C01_Grn.idat

200770460177_R06C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905384

LCBM-04

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

71

Female

Lung Cancer

Non-Small Cell Lung Cancer

137

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R01C02_Grn.idat

200770460177_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905385

LCBM-06

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

67

Female

Lung Cancer

Non-Small Cell Lung Cancer

328

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R02C02_Grn.idat

200770460177_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905386

LCBM-08

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

66

Female

Lung Cancer

Non-Small Cell Lung Cancer

18

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R04C02_Grn.idat

200770460177_R04C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905387

LCBM-09

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

63

Female

Lung Cancer

Non-Small Cell Lung Cancer

1146

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R05C02_Grn.idat

200770460177_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905388

LCBM-10

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

71

Female

Lung Cancer

Small Cell Lung Cancer

583

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200770460177_R06C02_Grn.idat

200770460177_R06C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905389

LCBM-12

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

86

Female

Lung Cancer

Non-Small Cell Lung Cancer

360

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R02C01_Grn.idat

200866140110_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905390

LCBM-14

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

67

Male

Lung Cancer

Small Cell Lung Cancer

1050

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R03C01_Grn.idat

200866140110_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905391

LCBM-15

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

88

Male

Lung Cancer

Non-Small Cell Lung Cancer

623

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R04C01_Grn.idat

200866140110_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905392

LCBM-16

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

69

Female

Lung Cancer

Non-Small Cell Lung Cancer

519

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R05C01_Grn.idat

200866140110_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905393

LCBM-17

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

64

Female

Lung Cancer

Non-Small Cell Lung Cancer

129

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R06C01_Grn.idat

200866140110_R06C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905394

LCBM-18

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

61

Male

Lung Cancer

Non-Small Cell Lung Cancer

277

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R01C02_Grn.idat

200866140110_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905395

LCBM-19

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

83

Female

Lung Cancer

Non-Small Cell Lung Cancer

975

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R02C02_Grn.idat

200866140110_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905396

LCBM-20

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

43

Male

Lung Cancer

Small Cell Lung Cancer

315

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R03C02_Grn.idat

200866140110_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905397

LCBM-21

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

76

Female

Lung Cancer

Non-Small Cell Lung Cancer

66

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R04C02_Grn.idat

200866140110_R04C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905398

LCBM-22

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

68

Female

Lung Cancer

Non-Small Cell Lung Cancer

11

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R05C02_Grn.idat

200866140110_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905399

MBM-09

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

60

Male

Melanoma

NRAS mutated

2995

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7310440033_R04C01_Grn.idat

7310440033_R04C01_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088546

MBM-10

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

63

Female

Melanoma

BRAF/NRAS wild type

5999

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7310440033_R05C01_Grn.idat

7310440033_R05C01_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088547

MBM-11

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

80

Male

Melanoma

N/A

1461

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

7786915145_R06C02_Grn.idat

7786915145_R06C02_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088548

MBM-12

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

44

Male

Melanoma

NRAS mutated

760

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7786923108_R02C01_Grn.idat

7786923108_R02C01_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088549

MBM-14

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

62

Male

Melanoma

BRAF mutated

943

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7786923108_R04C01_Grn.idat

7786923108_R04C01_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088551

MBM-15

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

45

Female

Melanoma

NRAS mutated

2404

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

7786923108_R05C01_Grn.idat

7786923108_R05C01_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088552

MBM-16

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

48

Female

Melanoma

BRAF mutated

1232

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

7786923108_R06C01_Grn.idat

7786923108_R06C01_Red.idat

Gene Expression Omnibus

GSE44661

GSM1088553

MBM-17

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

NA

Female

Melanoma

BRAF mutated

8187

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860098_R02C01_Grn.idat

200397860098_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905400

MBM-18

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

75

Female

Melanoma

NRAS mutated

3881

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200123460092_R01C01_Grn.idat

200123460092_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905401

MBM-19

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

56

Male

Melanoma

BRAF mutated

1185

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R05C01_Grn.idat

200397860045_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905402

MBM-20

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

70

Female

Melanoma

BRAF/NRAS wild type

3710

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200397860098_R05C01_Grn.idat

200397860098_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905403

MBM-21

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

56

Female

Melanoma

BRAF/NRAS wild type

2014

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200866140110_R06C02_Grn.idat

200866140110_R06C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905404

MBM-22

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

53

Male

Melanoma

NRAS mutated

2684

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R05C01_Grn.idat

200397540080_R05C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905405

MBM-23

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

73

Male

Melanoma

NRAS mutated

1187

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R06C02_Grn.idat

200397540080_R06C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905406

MBM-24

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

71

Male

Melanoma

NRAS mutated

2252

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R03C01_Grn.idat

200397860045_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905407

MBM-25

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

51

Male

Melanoma

BRAF mutated

3541

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R01C02_Grn.idat

200397540080_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905408

MBM-26

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

75

Male

Melanoma

NRAS mutated

2078

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860098_R03C02_Grn.idat

200397860098_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905409

MBM-27

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

82

Male

Melanoma

BRAF mutated

4217

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R04C02_Grn.idat

200397540080_R04C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905410

MBM-28

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

47

Male

Melanoma

BRAF mutated

4867

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R03C02_Grn.idat

200397540080_R03C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905411

MBM-29

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

74

Male

Melanoma

NRAS mutated

209

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

201031670094_R01C02_Grn.idat

201031670094_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905412

MBM-30

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

64

Male

Melanoma

BRAF/NRAS wild type

1296

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

201031670094_R02C02_Grn.idat

201031670094_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905413

MBM-31

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

72

Male

Melanoma

NRAS mutated

2465

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R04C01_Grn.idat

200397860045_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905414

MBM-32

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

46

Female

Melanoma

BRAF mutated

3207

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R02C02_Grn.idat

200397540080_R02C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905415

MBM-33

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

53

Male

Melanoma

BRAF mutated

654

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R01C02_Grn.idat

200397860045_R01C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905416

MBM-34

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

55

Male

Melanoma

NRAS mutated

1152

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R06C01_Grn.idat

200397860045_R06C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905417

MBM-35

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

62

Male

Melanoma

BRAF mutated

1000

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R01C01_Grn.idat

200397540080_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905418

MBM-36

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

40

Male

Melanoma

BRAF mutated

6684

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R03C01_Grn.idat

200397540080_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905419

MBM-37

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

58

Male

Melanoma

NRAS mutated

1383

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R06C01_Grn.idat

200397540080_R06C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905420

MBM-38

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

49

Female

Melanoma

BRAF mutated

6658

Alive

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R04C01_Grn.idat

200397540080_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905421

MBM-39

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

64

Male

Melanoma

BRAF mutated

1713

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

9305216131_R06C02_Grn.idat

9305216131_R06C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905422

MBM-40

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

55

Male

Melanoma

NRAS mutated

555

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R02C01_Grn.idat

200397540080_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905423

MBM-41

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

62

Female

Melanoma

NRAS mutated

119

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397540080_R05C02_Grn.idat

200397540080_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905424

MBM-42

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

32

Male

Melanoma

BRAF mutated

5648

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

9305216131_R05C02_Grn.idat

9305216131_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905425

MBM-43

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

48

Male

Melanoma

NRAS mutated

1895

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860098_R05C02_Grn.idat

200397860098_R05C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905426

MBM-44

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

72

Male

Melanoma

BRAF mutated

1810

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

9305216131_R04C02_Grn.idat

9305216131_R04C02_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905427

MBM-45

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

42

Female

Melanoma

BRAF mutated

919

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R02C01_Grn.idat

200397860045_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905428

MBM-46

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

80

Male

Melanoma

BRAF mutated

1716

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

8784241079_R04C01_Grn.idat

8784241079_R04C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905429

MBM-47

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

59

Male

Melanoma

BRAF mutated

1271

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7800246021_R03C01_Grn.idat

7800246021_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905430

MBM-48

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

56

Female

Melanoma

NRAS mutated

3471

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7310440033_R03C01_Grn.idat

7310440033_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905431

MBM-49

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

54

Male

Melanoma

NRAS mutated

1926

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7800246020_R01C01_Grn.idat

7800246020_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905432

MBM-50

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

44

Male

Melanoma

BRAF mutated

1688

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

200397860045_R01C01_Grn.idat

200397860045_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905433

MBM-51

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

77

Male

Melanoma

N/A

514

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

8784241079_R03C01_Grn.idat

8784241079_R03C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905434

MBM-52

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

73

Male

Melanoma

BRAF/NRAS wild type

904

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7800246021_R01C01_Grn.idat

7800246021_R01C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905435

MBM-53

Patient with brain metastasis

Homo sapiens

Brain metastasis

Microdissected formalin-fixed paraffin-embedded tissue

Tissue specimen collection

Histopathological classification of brain metastasis

Genomic DNA extraction

Genome-wide DNA methylation profiling

Data processing and analysis

54

Male

Melanoma

NRAS mutated

3719

Dead

Illumina Infinium 450K Human DNA methylation Beadchip

7800246021_R02C01_Grn.idat

7800246021_R02C01_Red.idat

Gene Expression Omnibus

GSE108576

GSM2905436