Figure 3: The performances of GXG and GXE analysis.

(a) Correlation results of 16 SNPs which showed statistically significant association with platinum-based chemotherapy in the discovery stage analyzed by gPLINK. Red and black dot represented the p-value of paired and single SNP analysis, respectively. (b) Illustrative performances of GMDR models of rs3776332-rs2228528-rs228589 -rs2977549-Histology. (c) Illustrative performances of GMDR models of rs3776332-rs2228528-rs4658-Histology. (d) Illustrative performances of GMDR models of rs2228528-rs2929970-Histology. Red and black line represented the statistical significance (I), accuracy (II), sensitivity (III), specificity (IV) and precision (V) of model and univariate analysis.