Figure 1: Experimental design and overview of ChIP targets.
From: ChIP-seq and ChIP-exo profiling of Pol II, H2A.Z, and H3K4me3 in human K562 cells
(a) K562 cells were cultured using standard conditions and harvested for ChIP-seq and ChIP-exo. ChIP-seq reports on the sonication borders of ChIP-enriched DNA fragments, wherein the location of the protein-DNA crosslink is deduced. In contrast, ChIP-exo sequences the exonuclease left and right borders that flank protein-DNA interactions. (b) Illustration of biological context of ChIP targets: Pol II, H2A.Z, and H3K4me3.
