Figure 4 | Signal Transduction and Targeted Therapy

Figure 4

From: G-protein-coupled receptors mediate 14-3-3 signal transduction

Figure 4

Interaction of 14-3-3 with a downstream effector, Raf-1. (a) Stimulation of the Raf-1/14-3-3 interaction by GPCR ligands: adrenaline, dopamine and NECA. (b)Time course of the Raf-1/14-3-3 interaction signals in response to adrenaline stimulation. (c) Concentration–response curve for FBS. (d) Inhibition of the FBS-stimulated Raf-1/14-3-3 interaction by kinase inhibitors: GW5074, vemurafenib and staurosporine. RLUs, relative light units.

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